I like to carry my S&W model 60 with a clipdraw brand clip. I carry it strong side apendix. For me, appendix works the best. I wear suspenders instead of a belt, so I can't really use a traditional holster. And I have no concerns about safety. Remember, your primary safety is between your ears.
Yeah, I can't draw while I'm sitting in my truck, but that's not an issue for me since I keep another pistol in my truck anyway. And if I'm riding in my wife's car I just slip the pistol under the seat or in the jockey box. Which works well since I use the clip draw and don't have to worry about a holster.
YMMV but it works for me.
Here's a pic