Oh, and on the point about barrel life...
Speed itself is not the enemy. Temperature and pressure are what kill barrels.
That 35gr load at 4,435 in a 24" 22-250 is only about 58,000psi, right below the threshold where barrel life begins to be an issue. That barrel will last just as long as it would shooting any other bullet and any other speed.
Still happily answering to the call-sign Peetza.
You do not HAVE a soul. You ARE a soul. You HAVE a body.
He is no fool who gives what he can not keep to gain what he can not lose.
-Jim Eliott, paraphrasing Philip Henry.