I think the PDX1 12ga rounds are a 1oz slug and 3 00buck shots in the same round. I don't think the slugs break up any more than other slugs.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 23 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple