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Yes, your .22 will work fine- as long as it's reliable and you do your part. A bigger caliber will give you a slight advantage.
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Yes, with any round you must do your part and place the shots accurately. But to do your part with a .22 and have it work fine you're going to need to be extremely accurate and fast; and even then you might need to be lucky, too. A bigger caliber like a good 9mm is going to offer much more than a slight advantage.
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People have been effectively using .22s for defense for over 100 years.
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True, but that doesn't mean there aren't better options, especially with today's hollow point 9mm, .40, and .45 ammo.