Bottom line is I would not deploy a .22lr (and I love the caliber) for HD/SD. Perhaps as a BUG but now the .380's are small enough to render the old Bobcats/Pt22/25's etc. tactically inferior IMO.
Now, if a 10/22 were to be used as a HD choice I would have much more faith in the .22lr but still would not opt for it as my first choice.
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“A free people ought...to be armed..."