I loved my .22-250 and while I found the 60 grain Hornady bullets didn't shoot especially well in my Remington (1 1/2 minute groups), they didn't keyhole. The 60 grain Nosler Partitions are a bit shorter and may be fine.
People are like rifles. Some are tried and true, having great eyes, personality, and fun to be with. Others never seem to hit the mark with you. Still others go off half-cocked. Still, it's nice to know most of them.