I like the 110 and 125 grain bullets. I cant explain why but the recoil "feels" better (even in hot loads)
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple