I carried a Single Six for years in snake and cougar country, never felt under gunned. Stupid accurate, which was much more important to me than power. It was southern colorado scrubland and I knew that my most likely target would be snakes. Most rattlers in that part of the country were pretty close to invisible. The ones that rattled I just walked away from, no big deal. A couple of them I wasn't paying enough attention, and got into a situation where I couldn't walk away. At that point I wanted ACCURACY and absolutely nothing else. I can't imagine trying to make those shots with fixed sights and a 2" barrel. .38 ammo is cheap, .22 ammo is much cheaper, and a .22mag is surprisingly effective, especially with a longer barrel. The small frame Single Six means that even with a longer barrel it doesn't weigh that much.
Gaily bedight, A gallant knight In sunshine and in shadow, Had journeyed long, Singing a song, In search of El Dorado