I think one missing point here is if the OP hand loads or not.
If he does not load his own then the 44 mag is the right caliber. There are some impressive 45 Colt rounds out there but I have never used them. 260 GR 1450 FPS and 1214 ft lbs.
“Peace is that brief glorious moment in history when everybody stands around reloading.” – Thomas Jefferson.
Politician's are like diapers.
You need to change them often,,,,, for the same reason!