I think one missing point here is if the OP hand loads or not.
If he does not load his own then the 44 mag is the right caliber. There are some impressive 45 Colt rounds out there but I have never used them. 260 GR 1450 FPS and 1214 ft lbs.
It was a sad day when I discovered my universal remote control did not in fact control the universe.
Did you hear about the latest study.....5 out of 6 liberals say that Russian Roulette is safe.