I've been spending a lot of time drooling over the P220 lately. This could be a great option for me, especially since I don't even mind larger frames (the Beretta 92-series are very comfortable for me). 10+1 of .45 is fully adequate, I think, same as the M&P45 and it avoids the massive brick grip of the 13+1 and 15+1 .45s.
Beretta PX4 Type F Fullsize .40 S&W | Beretta 92FS 9x19 Para | Beretta 8040 Cougar Type G .40 S&W | Rock Island Armory GI 1911 .45 ACP | Sig Sauer SP2022 Stainless 9x19 Para | Sig Sauer P6 9x19 Para | Colt Python 4" .357 Magnum | Colt 1968 Det. Spec. .38 Spc. | Ruger LCP .380 ACP | Daniel Defense M4V1 5.56x45 | Alpine M1 Carbine .30 | Steyr M1895 8x56 | Ruger 10/22 .22LR |1943 Izhevsk Mosin-Nagant M91/30 7.62x54R | Remington 870 12GA