I've been spending a lot of time drooling over the P220 lately. This could be a great option for me, especially since I don't even mind larger frames (the Beretta 92-series are very comfortable for me). 10+1 of .45 is fully adequate, I think, same as the M&P45 and it avoids the massive brick grip of the 13+1 and 15+1 .45s.
Beretta PX4 .40 S&W - Beretta 92FS 9x19 Para - Rock Island Armory GI 1911 .45 ACP - Colt 1968 Detective Special .38 Spc. - Ruger LCP .380 ACP - Daniel Defense M4V1 Carbine 5.56x45 - Ruger 10/22 .22LR - Remington 870 Express Tactical 12GA - 1943 Izhevsk Mosin-Nagant M91/30 7.62x54R