Leaves me thinking that a .45 with naturally subsonic 230gr JHP ammo is probably the ideal way to go for home defense. in terms of hearing loss anyway.
That's my thinking as well, with a twist. I use very tame (actually target load level) .45ACP 225 gr. full wadcutters (special order from Penn Bullets) or .38 special 148 gr. wadcutters in my HD revolvers. They are relatively heavy and cut a big(ger) hole in whatever they hit without worrying about whether or not the HP petals open up. A 158 gr. LSWCHP +P (FBI load) .38 special is also a good choice. The lead in the HP is soft and opens easily.