Look, so many things come into play when your talkin shooting humans that nothing can be written in stone. There are no absolutes. But as a civilian I'd hate to have to live on the difference (or lack there of) between the worst 125gr HP or SP loads and the best 158gr HP or SP loads and vice versa. If you really think that at across the room distance that the bullet weight or specialty(high priced) ammo is gonna mean life or death you need to stop and think a little.
I'm not saying go out and buy the cheapest hard ball or FMJ ammo you can find and call it good but HP to HP, SP to SP, quality vs. quality, etc bullet weight is gonna mean very little if anything when it comes to life or death.