What caliber is the rifle? Most high powered rifles and calibers these days sight 1.5 high at 100 are going to be very close at 200 and 6 to ten inches low at three hundred.
I would say use the same cross hair out to your zero range and then the full moa measurement past that. However what ever your moa measurement is will increase at longer range. Example if it is 8 moa that is about 8 inches at 100 yards the same 8 moa becomes 24 inches at 300 yards. It seems that with an 8 moa difference would not really be usefull until about 500 yards. It would be too much holdover much before then.