So long as you know how your shotgun shoots with what you'll be using, it shouldn't be a problem.
I often take my shotgun out with a slug in the chamber and buckshot in the tube once the hunt clubs start running dogs all over the place and making the deer go haywire. That way I have the slug ready in case a non-disturbed deer presents itself, but if I hear crashing through the woods I can just eject and pump the buckshot in for a close up moving shot if need be. Gotta love the versatility of a shotgun
---Perfection is achieved, not when there is nothing more to add, but when there is nothing left to take away.---
---Enlightenment is the ability to take infinite pains---