I keep a box of 357 magnum stashed in my glove compartment incase I forget my ammo on the way to the range.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple