Best all-around round? I'd say 357.
If the circumstance for having one calibur only was armageddon and a complete breakdown of civilization, I think I'd grab a 9mm. It seems that everybody and his uncle has one. If I had to search a dead body for ammo, it's not likely I'd find 357's.
Of course, with my luck, everywhere I searched, I'd only find 22WRF's.
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