1) Wilson or other completely reliable 1911. 45 ACP + double safety system + SA trigger. . .all good
2) XD 45 or 40 - Similar to above but a cheaper platform and holds a few more rounds. Lack of thumb safety kind of sucks, but maybe no need.
3) Glock 21 or 22 - Both super weapons, but just require more focus on technique, especially reholstering.
4) S&W 19 - Utterly reliable and still packs a good punch. Possibly the best grip size flexibility of the three.