ok this is not about any type or shape or brand or material or even weight gun so please don't go there.
If you hypathetically had the perfect handgun that took every caliber they made from .22 to .454 and you can only choose 1 caliber what caliber would you choose to carry everyday????
What is the purpose of this hypothetical carry gun?
Self defense against 2 legged and medium sized 4 legged critters, the same as I carry now. 357 Sig 125 Grn JHP @ 1500 FPS.