Can't offer much on the Ruger, others will chime in, but I am a fan of the Remmie, have several from several makers (Uberti, Pietta, ASM). I very often shoot them with conversion cylinders in both .45 LC and .45 ACP and enjoy them immensely. I also shoot them as cap and ball when the mood strikes. The Uberti's have been reliable and excellent shooters. I have a Pietta as well, with a ,45 ACP cylinder, and it's a fine shooter but I still hate the stupid markings on the barrel. I'd enjoy getting a Ruger just to compare to the Remmies, but cannot imagine that it is much better. Better sights... well.. yes, that would be an improvement. But then again, you can get "Target" versions of the Remmies.