The only way to tell for sure is to try it. Once in awhile you get a load that doesn't exit in a close enough same barrel time to that of another, allowing the barrel to deflect enough to throw the shot off a little. This is more a problem with thinner, lighter and more whippy barrels. But if you don't have that problem, at up to just over 200 yards, actual trajectories won't be different enough to affect hitting the kill zone of a deer.
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