If you're referring to the same powders we use to load rifle cartridges, the answer is a resounding NO!, with the exception of the Savage ML-10, ML-10II muzzleloaders and a few aftermarket barrels for TC Encore/Contenders.
If you're referring to a powder designed for muzzleloaders, well, yeah,
it's called "Black Powder", and various substitutes.
Still happily answering to the call-sign Peetza.
The problem, as you so eloquently put it, is choice.
He is no fool who gives what he can not keep to gain what he can not lose.
-Jim Eliott, paraphrasing Philip Henry.