Hmm, I shoot .22 lr, 9mm, .45 ACP and .45 Colt in handguns and all these cover any shooting I require. I reload for them all except, of course, the .22.
My favorite is the .45 ACP. I used to shoot .38 and .357 but as others have stated the .357 is just too much, with regard to muzzle blast, and the .45 Colt will do anything the .357 will, with less blast and no need to break the sound barrier to get the job done.
You must reload to be able to afford .45 Colt.