I gave up on .40S&W several years ago. I owned at least a half-dozen .40s, but never really found any of them indispensible.
About the same time, I gave up on .44 (Mag and Spl)--ammo too expensive, and since I don't live in big bear country...
Both of these decisions were made before I started handloading.,,but since that time, I have not been compelled to return to either.
These days, for revolvers, I own/load/shoot .357 Mag amd .41 Mag...and .45LC.
For semi autos, I load .45 acp and 10mm. I am set up to load 9mm, but shoot so little 9mm that I have not bothered.