I am a 100% certifiable 357 magnum fan boy. That said I can see the value in the 45LC. For my self I would pick the 357 magnum because it fits what I all ready have.But if I had to recommend to others I would say the 45 LC if you reload and the 357 if not.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...