I have an old Winchester 1904 single shot bolt action that is very accurate and really easy to carry. It is chambered in 22short/22long and 22extra long. It has had 22LR shot though it long before I was born. I found an only box of 22 extra-long and they still chambered but I was afraid to fire any.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 21 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple