I feel pretty much the same today about the various calibers that I own handguns for as I did when I first bought them. My interest in a particular caliber has come and gone and come back again. The 38spl and 357 mag are perfect examples of this.
I have never been a fan of the 25 ACP, 380 ACP, or 9mm and have been pretty neutral about the 45 ACP. I like the 40 S&W.
Some have become disenchanted with the big boomers (I define as 41 mag up). I would have to say that my interest in shooting them comes and goes. But I don't get rid of the guns and I will often shift interest and begin shooting them again. The 41 mag is in fact my favorite big boomer.
Never wanted to shoot rifle calibers in a handgun. But if I owned a Contender, it would be in 30-30 win.