Disenchanted with : .22LR and .38Spl. Shot .38 a whole lot in the '70s for Police Practical, then again many years later for CAS. But I found that with steel targets, spotters sometimes listen for the ping instead of watching for the dirt and I would get misses that I thought were unfair. Reloading cost difference with .45LC is not that great and a nice 200 or 250gr. bullet will give a much more satisfying and hearable sound off a steel.
Favorites: .45LC and .45ACP. Also like .22WMR in place of .22LR if I am buying ready-made fun ammo. The .22LR is for when the grandkids visit.