Glock 17 if for HD and range. If you added to be able to carry, I would say Glock 19. Night sights would be a plus for home defense and you could always add a light if you wanted.
Don't forget to store it where it is accessable to you in just a few seconds, but secure from anyone else that doesn't have permission. That will probably make your wife a little more comfortable as well.
Here's my HD Glock 17 w/night sights in a FAS1 handgun safe: