Here are the ones that have worked for me:
.22 LR: great for plinking, informal target shooting, small edible game, such as squirrels.
.38 Spl/.357 Magnum: The .38 Special loaded with 148 gr. Wadcutters in a mild target load for larger edible game, such as the big swamp rabbits (canecutters). Magnum loading for distant shots at crows, small varmints.
.44 Magnum: for medium game (deer) and long shots at groundhog, etc.
.45 Colt: Never got to use this on some big heavy game. Once contemplated taking buffalo, but never came to pass. Had a good 350 gr. load for one, though.