My Brother has a 50BMG Bolt gun that he lets me "borrow" the only rule is that he comes with me. It is a lot of fun on ground squirrels.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 23 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple