Have you handled a 1911? They're not for everybody, but they are simply the best for me. I have 3, two in .45 ACP and one in 10mm. One is my EDC for the last 8 or 9 years. With medium hands, you will probably prefer a flat mainspring housing. My rather large hands prefer an arched MSH, though my EDC has a flat, so hand-filling grips were part of the fix to make it perfect for me. A 1911 has many variations of size, personalizations like grips affect fit, and there are many different cartridge choices. I am still missing a Commander-sized one in 9mm. Someday for sure. Certainly check out the 1911s. But beware. You can't have just one.
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I am the weapon; my gun is a tool. It's regrettable that with some people those descriptors are reversed.