In my opinion, yes. I think 300 gr bullet is plenty excessive enough for a 44 Mag. I have a load that drives a 300 gr boolit to 1401 fps and shooting it shows me that I really don't need it, or at least at 1400. The 245 gr bullet will do alot more than people give it credit for. At times I thnk even the 300s are in all practicality, unneeded. Just a little added insurance.
YMMV, but I doubt it.