My Carry Load is Buffalo bore 357 magnum 125 grain "tactical low flash" If you can look at the bullets get the speer gold dots and not the Montana gold HP.
My home defence load is 2 3/4in 00 buck shot.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple