In competition, plugging a "no-shoot" will hurt your score. In real life shooting a "no-shoot" is at least likely to significantly damage your bank balance -- plus you will need to live with the fact that you shot, and perhaps disabled or killed, an upstanding member of the community.
"It is long been a principle of ours that one is no more armed because he has possession of a firearm than he is a musician because he owns a piano. There is no point in having a gun if you are not capable of using it skillfully." -- Jeff Cooper