What you said isn't really relevant. The OP said "I've never shot anything beyond 200 yards." and "expect 250-500 yards."
Beyond 200 yards.
It is unethical to shoot animals at distances you've never shot. Never shot anything. Not, "not this gun", not, "not this caliber", not "woodchucks but not elk"...
400 yards is not easy. The first bullet someone fires at that distance should NOT be at a live target.
400 is much harder than 200 and 500 is much harder than 400. Taking those shots without practice would be unethical.
Still happily answering to the call-sign Peetza.
The problem, as you so eloquently put it, is choice.
He is no fool who gives what he can not keep to gain what he can not lose.
-Jim Eliott, paraphrasing Philip Henry.