How accurate do you need to be? I have a NAA mini revolver in 22 short that I can hit pop cans with at 15 feet at about 75% accuracy, that should be good enough for self defense.
The NAA 22 shot is very small and light. It is better than harsh words for self defense... slighlty
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...