Funny you should ask. I just got home a little while ago from the shooting range where I shot my newly purchased Buffalo Bore 380 100gr +P FNHC. Wow. I've shot all kinds of ammo through my ol' Colt Mustang and nothing even vaguely caught my attention. My wife calls that gun "Baby" because it is so pleasant to shoot. You could definitely
tell the difference between BB load and anything else I've shot through it. Much snappier. Not a problem whatsoever, but definitely snappier. I recently saw a 31" penetration test on youtube for this load. Me likes it aLOT!
A big plus, if the bullet doesn't hurt the bad guy enough, maybe the cloud of dusty smoke that pours from it will temporarily blind him enough for you to make a get away.