In my younger days, I have shot a few animals when living on a farm in the summer. Dogs, racoons, ground hogs etc. I remember shooting a racoon that was up in a tree. I was the first living creature I had ever shot with a .357 magnum revolver. I expected it to get blown right out of the tree. I was really surprised when it took the whole cylinder full to get that racoon on the ground.
On the opposite end, I have shot 300 lb pigs in the kill pen with a 22 rimfire that dropped them where they stood.
It is where you make the hole that determines the lethality. I would say a .380 is quite lethal when you use it to make the hole in the right place.
Make a hole