Wait, wait, wait Mike Irwin. I think you are behind the times. I hear-tell that the 45 acp is an old fart that can't kill a salamander. Nowadays, the internet tells me that the real savage is the 9mm. With the new-fangled bullet designs, it is better than anything out there. I understand that if you are attacked, you can shoot it the opposite way and it will go around the world and blow the guys head completely off from behind. I think if the 9mm had a proper name, it would be Chuck Norris.
Other than that supernatural round, the 380 obviously is lethal, but has penetration issues. I've got a box of Buffalo Bore 100gr FNHC that I keep in my 380 Mustang to give it as much "oomph" as possible.