"Can you rely upon it to QUICKLY STOP an aggressive human bent on causing you bodily harm?"
You can't rely on any handgun to do that.
All you can hope for is small notches of "better at that".
Hell, even with a shotgun a quick stop isn't 100% guaranteed.
"The gift which I am sending you is called a dog, and is in fact the most precious and valuable possession of mankind" -Theodorus Gaza
Baby Jesus cries when the fat redneck doesn't have military-grade firepower.