Sometmes, sometimes not. After I confirm zero on my hunting rifles I will not remove the action from the stock until after hunting season unless it is an emergency.
After the season is over they are broken down for a good cleaning. After putting them back together in rare cases I may need to fire a few rounds to get the accuracy I was getting before, but I've never had to make scope adjustments.
Most of the time there are no changes at all. But I'd not trust the gun until I'd fired a few shots just to confirm that everyhing is OK. The key is to put everything back together correctly and tighten the action screws in the right sequnce and to the proper torque the same way every time.