For some reason, the first thing that came to mind was a 2-bore / 2-bore combination
1/2 pound of lead on top of 350 gr FFg... for a "light" load.
(Not my build. Not my rifle. Just something I've been following.)
I do a lot of shooting in conditions where handgun cartridges are less than ideal. So, I'm not much of a fan of the idea.
But... I'd say I would probably go with a .44 Mag pairing, if the situation were to arise.