My brother has a suppressed Ruger bolt action 44magnum. When loaded with 44 specials that thing is crazy quiet. It was the reason I got my 45/70 suppressed. I know it seems daunting and the wait time is a pain but shooting with a suppressor makes shooting a completely different game.
While most guns will never be movie quiet a suppressor will make a world of difference.
obvously know your state laws to make sure its ok where you live.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 25 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple