The issue, really, is less about the cartridge than it is about the length of time needed to go into action if attacked or threatened with attack.
I live in mountain lion country. While not particularly worried about them, I operate on the basis of a slung rifle in wide-open areas, in-hand in "possible" or rather close-cover areas and in canyons.
When quail hunting, I've often carried a Redhawk in a cross-draw rig. Not that I'm recommending a .44 Maggie, but the holster's location seemed convenient.
You're from BATFE? Come right in! I use all your fine products!