Weight and 'dress' are often the factors I go by. I might have a Jennings 22 one day, or the Beretta or Taurus PT22's, or my 3913, or Ruger SS357 and I've even carried my SRH in 44Mag. I feel comfortable will any of them at any time.
I may even get a G27 to match a G26 I'm fond of. Wife keeps taking off with that last one.
I've also carried a Colt Commamder, 1911, and even the wife's TCP. I've found all the be accurate and reliable. Now, if I could just get an Alaskan I like!
Mostly though, I think I prefer the 9mm G26 most of all.
Member, GoA, NRA-ILA, SAF, NRA Life Member