For heavy loads, use a 240 grain jacketed on top of Alliant 2400 or Hodgdon H110.
Hodgdon warns that you should not reduce H110
Reduce H110 and Winchester 296 loads 3% and work up from there. H110 and Winchester 296 if reduced too much will cause inconsistent ignition. In some cases it will lodge a bullet in the barrel, causing a hazardous situation (Barrel Obstruction). This may cause severe personal injury or death to users or bystanders. DO NOT REDUCE H110 LOADS BY MORE THAN 3%.