While I do think that one can adapt to any handgun via simple practice, I also see that initial comfort that one feels when gripping the gun for the first time as only increasing/accentuating the shooter's prospective accuracy capabilities.
Not to make an oversimplified analogy, but remember when you were comparing the baseball bats in Little League in that sometimes seemingly elusive search for that "perfect feeling" bat you were sure would result in a Ted Williams-like .400 bat. ave. (wow does that bring back some great memories of thirty years ago
). I think the same type of "feeling" applies to that "perfect" handgun.