One thing that surprises me is how much "feel in hand" can change over time.
I always figured it was a static variable, and so about a year and a half ago when I got to handle an M&P9c, I thought it was the most ergonomic, comfortable handgun ever. Fast forward a year and a half later, I grabbed a M&P40c a few days ago and I did not think it was comfortable at ALL. I have no idea what precipitated the change.
There are, though, undoubtedly guns that just plain fit you. My PX4 feels as good as it did the first day I got it over 4 years ago, and I've held the Gen4 Glock 19 about a half-dozen times and I think it feels completely phenomenal, to the point that I'm about settled on getting one.
Beretta PX4 .40 S&W - Beretta 92FS 9x19 Para - Rock Island Armory GI 1911 .45 ACP - Colt 1968 Detective Special .38 Spc. - Ruger LCP .380 ACP - Daniel Defense M4V1 Carbine 5.56x45 - Alpine Industries M1 Carbine .30 - Steyr-Mannlicher M1895 8x56 - Ruger 10/22 .22LR - Remington 870 Express Tactical 12GA - 1943 Izhevsk Mosin-Nagant M91/30 7.62x54R