One thing that surprises me is how much "feel in hand" can change over time.
I always figured it was a static variable, and so about a year and a half ago when I got to handle an M&P9c, I thought it was the most ergonomic, comfortable handgun ever. Fast forward a year and a half later, I grabbed a M&P40c a few days ago and I did not think it was comfortable at ALL. I have no idea what precipitated the change.
There are, though, undoubtedly guns that just plain fit you. My PX4 feels as good as it did the first day I got it over 4 years ago, and I've held the Gen4 Glock 19 about a half-dozen times and I think it feels completely phenomenal, to the point that I'm about settled on getting one.
Beretta PX4 Type F Fullsize .40 S&W | Beretta 92FS 9x19 Para | Beretta 8040 Cougar Type G .40 S&W | Rock Island Armory GI 1911 .45 ACP | Sig Sauer SP2022 Stainless 9x19 Para | Sig Sauer P6 9x19 Para | Colt Python 4" .357 Magnum | Colt 1968 Det. Spec. .38 Spc. | Ruger LCP .380 ACP | Daniel Defense M4V1 5.56x45 | Alpine M1 Carbine .30 | Steyr M1895 8x56 | Ruger 10/22 .22LR |1943 Izhevsk Mosin-Nagant M91/30 7.62x54R | Remington 870 12GA