One thing that surprises me is how much "feel in hand" can change over time.
I always figured it was a static variable, and so about a year and a half ago when I got to handle an M&P9c, I thought it was the most ergonomic, comfortable handgun ever. Fast forward a year and a half later, I grabbed a M&P40c a few days ago and I did not think it was comfortable at ALL. I have no idea what precipitated the change.
There are, though, undoubtedly guns that just plain fit you. My PX4 feels as good as it did the first day I got it over 4 years ago, and I've held the Gen4 Glock 19 about a half-dozen times and I think it feels completely phenomenal, to the point that I'm about settled on getting one.
16 Pistols, 5 Rifles, 1 Shotgun, no time to shoot them