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.454 for serious power. The only reason the +P .44 gets close to .454 from Buffalo Bore is that Buffalo Bore will not load the .454 to max as they are concerned the .454 will jump crimp due to insane power. I would be happy with a .45 Colt that could handle "Ruger Only" loads as that will kill anything on earth and that is enough for me. We know the .45 Colt will be around as long as anything else. I would not worry about the .454 going away.
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