Colt DA revolvers have only one locking point for the cylinder/crane assembly at the rear of the cylinder. S&W and Ruger DA revolvers lock both at the rear of the cylinder and the end of the ejector rod (most S&W's and Ruger Six Series) or on the crane (Ruger GP100, Redhawk, Super Redhawk, SP101, and LCR).
I know that, having had more than a few of each. My point was, what does cylinder rotation have to do with lock up? A Colt could just as easily have a push button cylinder release with a through pin front lock similar to the Smith.